The guy in the picture is Hugh Laurie, an English comedian of long standing (his career spans a little over 4 decades), more recently (for about 15 years or more) regularly acting in the US (not always in comedy). You may have seen him in 'Stuart Little' for example. If you get the chance, take a look at some of his older comedy work.

The character who said those words is Gregory House, an atheist doctor loosely based on the character of Sherlock Holmes (seriously), from the TV show House, which has been running for 8 years but recently (some months back) finished. He's a manipulative, utterly selfish, misanthropic sociopathic misfit with a drug problem, who also happens to be really smart.

The picture and quote have been posted countless times.