That was kinda my point; I figure the Genome is a term for the genetic information that exists as a physical entity (genes, chromosomes) that exist because of a process with no 'creator'. Conversely, the inverse square law of gravitation, fractals, and Relativity are theories - or accepted as knowledge in lieu of a more fitting theory - that has been created by humans to describe (or model) physical phenomena. In our current scientific and mathematical paradigms they may be considered truth, but if we come to a deeper or more insightful understanding of physical phenomena by research and new evidence, they may be subject to change.

tl;dr - theories and knowledge share the same domain: constructs; a biological entity is not.