People in general are insensitive and inconsiderate

On what do you base that claim? Sweeping generalizations like that have no place in reasonable discussion, and you know that. You're better than this.

Some people might make fun of some conditions because they look funny to them, they don't understand them, they are insecure because they have it too, they were given the wrong ideas about them, or they are just mean.

What's your point? The entirely of comedy is based on context and the ability to look at a situation from different, often conflicting, perspectives. Step outside yourself for a second. Everything is funny, everything, so long as you can move past your own position long enough to understand why.

I don't think any disorder, condition or disease should be made fun of, because its an issue of perspective.

The issue of perspective is precisely what makes something funny.

There is a difference between something legitimately being funny and putting someone down for another person's benefit.

How do you differentiate between legitimate humour and illegitimate humour? If someone finds something funny, that thing is by definition funny even if only to them. You personally finding something not funny in no way creates an objective truth in which that topic is suddenly not allowed to be found funny. By what authority do you or anyone else determine what is safe to be made fun of and what is not?

When humor is at its most offensive is when we need it most. Comedy is supposed to provoke, supposed to offend, supposed to challenge our pre-conceived notions precisely because it forces us to look at ourselves in a way we hadn't before.

Yes, humour can alienate, but that risk is something we need to be mature enough to accept. The alternative is censorship. We're thinking, reasoning adults and we deserve the right live free from any kind of censorship. Any kind.

Sometimes, humor is the only way we can deal with grim reality. The hilarity of the human condition is that we don't all get the same deal. We're all screwed in one way or another, and that's pure comedy gold.

Either everything can and should be made fun of, or nothing can and should be made fun of. Which world would you rather live in?