I think it's the other way around. The imaginary friends leaving is happening in her own head, so it's not so much that people are abandoning her later in life it's that she is afraid that people will abandon her later in life, even though it's obviously not true, because of the psychological trauma. If you think about it, a stuffed animal can never leave a person, just as nobody would decide to abandon a friend after they discovered they were abused. So I think the stuffed animal is just there to represent the friends that she doesn't allow herself to have, rather than friends that would abandon her, or whatever.

Anyways, very interesting comic. Makes you think.